The Ward Lab has 303 current publications in Pubmed.
Publication Date Journal Title and Authors
July 28 2023 STAR Protoc. Protocol for analyzing antibody responses to glycoprotein antigens using electron-microscopy-based polyclonal epitope mapping.
Turner HL, Jackson AM, Richey ST, Sewall LM, Antanasijevic A, Hangartner L, Ward AB.
July 28 2023 Nat Commun. Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.
Martin GM, Torres JL, Pholcharee T, Oyen D, Flores-Garcia Y, Gibson G, Moskovitz R, Beutler N, Jung DD, Copps J, Lee WH, Gonzalez-Paez G, Emerling D, MacGill RS, Locke E, King CR, Zavala F, Wilson IA, Ward AB.
July 25 2023 Immunity. Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo.
Hansen L, McMahon M, Turner HL, Zhu X, Turner JS, Ozorowski G, Stadlbauer D, Vahokoski J, Schmitz AJ, Rizk AA, Alsoussi WB, Strohmeier S, Yu W, Choreño-Parra JA, Jiménez-Alvarez L, Cruz-Lagunas A, Zúñiga J, Mudd PA, Cox RJ, Wilson IA, Ward AB, Ellebedy AH, Krammer F.
July 13 2023 NPJ Vaccines. Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens.
Martin GM, Russell RA, Mundsperger P, Harris S, Jovanoska L, Trajano LF, Schiffner T, Fabian K, Tolazzi M, Scarlatti G, McFarlane L, Cheeseman H, Aldon Y, Schermer EE, Breemen M, Sliepen K, Katinger D, Kunert R, Sanders RW, Shattock R, Ward AB, Sattentau QJ.
June 26 2023 Cell Rep Methods Increasing sensitivity of antibody-antigen interactions using photo-cross-linking.
Torrents de la Peña A, Sewall LM, de Paiva Froes Rocha R, Jackson AM, Pratap PP, Bangaru S, Cottrell CA, Mohanty S, Shaw AC, Ward AB.
June 6 2023 Proc Natl Acad Sci U S A Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG.
May 31 2023 Front Immunol Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response.
Bale S, Yang L, Alirezaei M, Wilson R, Ota T, Doyle ED, Cottrell CA, Guenaga J, Tran K, Li W, Stamatatos L, Nemazee D, Ward AB, Wyatt RT.
May 27 2023 Retrovirology Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization.
Colin P, Ringe RP, Yasmeen A, Ozorowski G, Ketas TJ, Lee WH, Ward AB, Moore JP, Klasse PJ.
May 18 2023 Cell Rep. Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies.
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Müller-Kräuter H, Müller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB.
May 17 2023 Nat Commun. Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9.
Martin GM, Fernández-Quintero ML, Lee WH, Pholcharee T, Eshun-Wilson L, Liedl KR, Pancera M, Seder RA, Wilson IA, Ward AB.
April 25 2023 Commun Biol. Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine.
Dzimianski JV, Han J, Sautto GA, O'Rourke SM, Cruz JM, Pierce SR, Ecker JW, Carlock MA, Nagashima KA, Mousa JJ, Ross TM, Ward AB, DuBois RM.
April 21 2023 iScience. Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses.
Radi? L, Sliepen K, Yin V, Brinkkemper M, Capella-Pujol J, Schriek AI, Torres JL, Bangaru S, Burger JA, Poniman M, Bontjer I, Bouhuijs JH, Gideonse D, Eggink D, Ward AB, Heck AJR, Van Gils MJ, Sanders RW, Schinkel J.
April 8 2023 Nat Commun. Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates.
Zhang YN, Paynter J, Antanasijevic A, Allen JD, Eldad M, Lee YZ, Copps J, Newby ML, He L, Chavez D, Frost P, Goodroe A, Dutton J, Lanford R, Chen C, Wilson IA, Crispin M, Ward AB, Zhu J.
April 3 2023 Cell Rep Med. Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.
Caniels TG, Medina-Ramírez M, Zhang J, Sarkar A, Kumar S, LaBranche A, Derking R, Allen JD, Snitselaar JL, Capella-Pujol J, Sánchez IDM, Yasmeen A, Diaz M, Aldon Y, Bijl TPL, Venkatayogi S, Martin Beem JS, Newman A, Jiang C, Lee WH, Pater M, Burger JA, van Breemen MJ, de Taeye SW, Rantalainen K, LaBranche C, Saunders KO, Montefiori D, Ozorowski G, Ward AB, Crispin M, Moore JP, Klasse PJ, Haynes BF, Wilson IA, Wiehe K, Verkoczy L, Sanders RW.
April 1 2023 Ann N Y Acad Sci. Respiratory viruses: New frontiers-a Keystone Symposia report.
Cable J, Sun J, Cheon IS, Vaughan AE, Castro IA, Stein SR, López CB, Gostic KM, Openshaw PJM, Ellebedy AH, Wack A, Hutchinson E, Thomas MM, Langlois RA, Lingwood D, Baker SF, Folkins M, Foxman EF, Ward AB, Schwemmle M, Russell AB, Chiu C, Ganti K, Subbarao K, Sheahan TP, Penaloza-MacMaster P, Eddens T.
March 8 2023 Proc Natl Acad Sci U S A Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains.
Wang JYJ, Khmelinskaia A, Sheffler W, Miranda MC, Antanasijevic A, Borst AJ, Torres SV, Shu C, Hsia Y, Nattermann U, Ellis D, Walkey C, Ahlrichs M, Chan S, Kang A, Nguyen H, Sydeman C, Sankaran B, Wu M, Bera AK, Carter L, Fiala B, Murphy M, Baker D, Ward AB, King NP.
March 2 2023 J Clin Invest. Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct Omicron subvariants.
Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC.
December 22 2022 iScience Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses.
Brinkkemper M, Veth TS, Brouwer PJM, Turner H, Poniman M, Burger JA, Bouhuijs JH, Olijhoek W, Bontjer I, Snitselaar JL, Caniels TG, van der Linden CA, Ravichandran R, Villaudy J, van der Velden YU, Sliepen K, van Gils MJ, Ward AB, King NP, Heck AJR, Sanders RW.
December 21 2022 Nat Commun. Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site.
Stadlbauer D, McMahon M, Turner HL, Zhu X, Wan H, Carreño JM, O'Dell G, Strohmeier S, Khalil Z, Luksza M, van Bakel H, Simon V, Ellebedy AH, Wilson IA, Ward AB, Krammer F.
December 14 2022 Cell Host Microbe Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
Brouwer PJM, Antanasijevic A, Ronk AJ, Müller-Kräuter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW.
November 25 2022 NPJ Vaccines. Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates.
Reiss EIMM, van Haaren MM, van Schooten J, Claireaux MAF, Maisonnasse P, Antanasijevic A, Allen JD, Bontjer I, Torres JL, Lee WH, Ozorowski G, Vázquez Bernat N, Kaduk M, Aldon Y, Burger JA, Chawla H, Aartse A, Tolazzi M, Gao H, Mundsperger P, Crispin M, Montefiori DC, Karlsson Hedestam GB, Scarlatti G, Ward AB, Le Grand R, Shattock R, Dereuddre-Bosquet N, Sanders RW, van Gils MJ.
November 25 2022 Nat Commun. Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate.
Sliepen K, Radi? L, Capella-Pujol J, Watanabe Y, Zon I, Chumbe A, Lee WH, de Gast M, Koopsen J, Koekkoek S, Del Moral-Sánchez I, Brouwer PJM, Ravichandran R, Ozorowski G, King NP, Ward AB, van Gils MJ, Crispin M, Schinkel J, Sanders RW.
November 17 2022 PLoS Pathog. Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
van Schooten J, Schorcht A, Farokhi E, Umotoy JC, Gao H, van den Kerkhof TLGM, Dorning J, Rijkhold Meesters TG, van der Woude P, Burger JA, Bijl T, Ghalaiyini R, Torrents de la Peña A, Turner HL, Labranche CC, Stanfield RL, Sok D, Schuitemaker H, Montefiori DC, Burton DR, Ozorowski G, Seaman MS, Wilson IA, Sanders RW, Ward AB, van Gils MJ.
November 15 2022 Angew Chem Int Ed Engl. An Infectious Virus-like Particle Built on a Programmable Icosahedral DNA Framework.
Xu Y, Yang YR, Shi Q, Ward AB, Huang K, Chen X, Wang W, Yang Y.
November 4 2022 PNAS Nexus. High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions.
Antanasijevic A, Schulze AJ, Reddy VS, Ward AB.
October 21 2022 Science Structure of the hepatitis C virus E1E2 glycoprotein complex.
Torrents de la Peña A, Sliepen K, Eshun-Wilson L, Newby ML, Allen JD, Zon I, Koekkoek S, Chumbe A, Crispin M, Schinkel J, Lander GC, Sanders RW, Ward AB.
September 26 2022 Immunity Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors.
Willis JR, Berndsen ZT, Ma KM, Steichen JM, Schiffner T, Landais E, Liguori A, Kalyuzhniy O, Allen JD, Baboo S, Omorodion O, Diedrich JK, Hu X, Georgeson E, Phelps N, Eskandarzadeh S, Groschel B, Kubitz M, Adachi Y, Mullin TM, Alavi NB, Falcone S, Himansu S, Carfi A, Wilson IA, Yates JR 3rd, Paulson JC, Crispin M, Ward AB, Schief WR.
September 26 2022 Cell Rep Med. Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens.
Kraft JC, Pham MN, Shehata L, Brinkkemper M, Boyoglu-Barnum S, Sprouse KR, Walls AC, Cheng S, Murphy M, Pettie D, Ahlrichs M, Sydeman C, Johnson M, Blackstone A, Ellis D, Ravichandran R, Fiala B, Wrenn S, Miranda M, Sliepen K, Brouwer PJM, Antanasijevic A, Veesler D, Ward AB, Kanekiyo M, Pepper M, Sanders RW, King NP.
September 22 2022 Cell Rep Med. Innate cell markers that predict anti-HIV neutralizing antibody titers in vaccinated macaques.
Van Tilbeurgh M, Maisonnasse P, Palgen JL, Tolazzi M, Aldon Y, Dereuddre-Bosquet N, Cavarelli M, Beignon AS, Marcos-Lopez E, Gallouet AS, Gilson E, Ozorowski G, Ward AB, Bontjer I, McKay PF, Shattock RJ, Scarlatti G, Sanders RW, Le Grand R.
September 22 2022 Immunity Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice.
Melzi E, Willis JR, Ma KM, Lin YC, Kratochvil S, Berndsen ZT, Landais EA, Kalyuzhniy O, Nair U, Warner J, Steichen JM, Kalyuzhniy A, Le A, Pecetta S, Perez M, Kirsch K, Weldon SR, Falcone S, Himansu S, Carfi A, Sok D, Ward AB, Schief WR, Batista FD.
September 21 2022 Nature Long-primed germinal centres with enduring affinity maturation and clonal migration
Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torre JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S.
September 6 2022 Nat Commun Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus.
Zhao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D.
August 11 2022 iScience Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways.
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG.
August 10 2022 Sci Transl Med Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques.
He WT, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee WH, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Irvine DJ, Ward AB, Wilson IA, Burton DR, Andrabi R.
August 10 2022 Immunity Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus.
Sangesland M, Torrents de la Peña A, Boyoglu-Barnum S, Ronsard L, Mohamed FAN, Moreno TB, Barnes RM, Rohrer D, Lonberg N, Ghebremichael M, Kanekiyo M, Ward A, Lingwood D.
August 4 2022 Nat Commun A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike.
Claireaux M, Caniels TG, de Gast M, Han J, Guerra D, Kerster G, van Schaik BDC, Jongejan A, Schriek AI, Grobben M, Brouwer PJM, van der Straten K, Aldon Y, Capella-Pujol J, Snitselaar JL, Olijhoek W, Aartse A, Brinkkemper M, Bontjer I, Burger JA, Poniman M, Bijl TPL, Torres JL, Copps J, Martin IC, de Taeye SW, de Bree GJ, Ward AB, Sliepen K, van Kampen AHC, Moerland PD, Sanders RW, van Gils MJ.
August 4 2022 Immunity Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses.
Tas JMJ, Koo JH, Lin YC, Xie Z, Steichen JM, Jackson AM, Hauser BM, Wang X, Cottrell CA, Torres JL, Warner JE, Kirsch KH, Weldon SR, Groschel B, Nogal B, Ozorowski G, Bangaru S, Phelps N, Adachi Y, Eskandarzadeh S, Kubitz M, Burton DR, Lingwood D, Schmidt AG, Nair U, Ward AB, Schief WR, Batista FD
August 3 2022 Elife Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels.
Teng B, Kaplan JP, Liang Z, Krieger Z, Tu YH, Burendei B, Ward AB, Liman ER.
August 3 2022 Nat Commun Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein.
van Schooten J, Farokhi E, Schorcht A, van den Kerkhof TLGM, Gao H, van der Woude P, Burger JA, Meesters TGR, Bijl T, Ghalaiyini R, Turner HL, Dorning J, van Schaik BDC, van Kampen AHC, Labranche CC, Stanfield RL, Sok D, Montefiori DC, Burton DR, Seaman MS, Ozorowski G, Wilson IA, Sanders RW, Ward AB, van Gils MJ.
July 22 2022 Sci Immunol A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.
Sahoo A, Jones AT, Cheedarla N, Gangadhara S, Roy V, Styles TM, Shiferaw A, Walter KL, Williams LD, Shen X, Ozorowski G, Lee WH, Burton S, Yi L, Song X, Qin ZS, Derdeyn CA, Ward AB, Clements JD, Varadarajan R, Tomaras GD, Kozlowski PA, Alter G, Amara RR.
June 13 2022 J Immunol. The Pre-Existing Human Antibody Repertoire to Computationally Optimized Influenza H1 Hemagglutinin Vaccines.
Nagashima K, Dzimianski JV, Han J, Abbadi N, Gingerich AD, Royer F, O'Rourke S, Sautto GA, Ross TM, Ward AB, DuBois RM, Mousa JJ.
June 2 2022 Nat Immunol. Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schäfer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R.
June 1 2022 Chembiochem. Conjugation of a Toll-like Receptor Agonist to Glycans of an HIV Native-like Envelope Trimer Preserves Neutralization Epitopes.
Li Z, Derking R, Lee WH, Bosman GP, Ward AB, Sanders RW, Boons GJ.
May 20 2022 Proc Natl Acad Sci U S A Influenza chimeric hemagglutinin structures in complex with broadly protective antibodies to the stem and trimer interface.
Zhu X, Han J, Sun W, Puente-Massaguer E, Yu W, Palese P, Krammer F, Ward AB, Wilson IA.
May 12 2022 Proc Natl Acad Sci U S A. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB.
May 4 2022 Sci Adv Structural mapping of antibody landscapes to human betacoronavirus spike proteins
Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Peña AT, Crowe JE Jr, Ward AB.
April 28 2022 PLoS Pathog A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant
Hingankar N, Deshpande S, Das P, Rizvi ZA, Wibmer CK, Mashilo P, Ansari MY, Burns A, Barman S, Zhao F, Mukherjee S, Torres JL, Chattopadhyay S, Mehdi F, Sutar J, Rathore DK, Pargai K, Singh J, Sonar S, Jakhar K, Dandotiya J, Bhattacharyya S, Mani S, Samal S, Singh S, Kshetrapal P, Thiruvengadam R, Batra G, Medigeshi G, Ward AB, Bhatnagar S, Awasthi A, Sok D, Bhattacharya J.
April 11 2022 Commun Biol. Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
Hurlburt NK, Homad LJ, Sinha I, Jennewein MF, MacCamy AJ, Wan YH, Boonyaratanakornkit J, Sholukh AM, Jackson AM, Zhou P, Burton DR, Andrabi R, Ozorowski G, Ward AB, Stamatatos L, Pancera M, McGuire AT.
March 1 2022 Cell Rep Structure-guided changes at the V2 apex of HIV-1 clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies
Sahoo A, Hodge EA, LaBranche CC, Styles TM, Shen X, Cheedarla N, Shiferaw A, Ozorowski G, Lee WH, Ward AB, Tomaras GD, Montefiori DC, Irvine DJ, Lee KK, Amara RR.
February 28 2022 NPJ Vaccines. High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers.
Del Moral-Sánchez I, Russell RA, Schermer EE, Cottrell CA, Allen JD, Torrents de la Peña A, LaBranche CC, Kumar S, Crispin M, Ward AB, Montefiori DC, Sattentau QJ, Sliepen K, Sanders RW.
February 14 2022 Nat Commun. Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1
Jojoa-Cruz S, Saotome K, Tsui CCA, Lee WH, Sansom MSP, Murthy SE, Patapoutian A, Ward AB
January 19 2022 Sci Adv From structure to sequence: Antibody discovery using cryoEM.
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB.
January 10 2022 Front Immunol . Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development
Murin CD, Gilchuk P, Crowe JE Jr, Ward AB.
December 23 2021 Nature Broadly neutralizing antibodies target a hemagglutinin anchor epitope.
Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O'Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC.
November 2 2021 Cell Rep. Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies.
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD.
October 28 2021 Cell Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Gilchuk P, Murin CD, Cross RW, Ilinykh PA, Huang K, Kuzmina N, Borisevich V, Agans KN, Geisbert JB, Zost SJ, Nargi RS, Sutton RE, Suryadevara N, Bombardi RG, Carnahan RH, Bukreyev A, Geisbert TW, Ward AB, Crowe JE Jr.
October 20 2021 Sci Transl Med. Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.
Cho H, Gonzales-Wartz KK, Huang D, Yuan M, Peterson M, Liang J, Beutler N, Torres JL, Cong Y, Postnikova E, Bangaru S, Talana CA, Shi W, Yang ES, Zhang Y, Leung K, Wang L, Peng L, Skinner J, Li S, Wu NC, Liu H, Dacon C, Moyer T, Cohen M, Zhao M, Lee FE, Weinberg RS, Douagi I, Gross R, Schmaljohn C, Pegu A, Mascola JR, Holbrook M, Nemazee D, Rogers TF, Ward AB, Wilson IA, Crompton PD, Tan J.
October 20 2021 J Virol. The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization.
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW.
October 15 2021 Emerg Microbes Infect. One dose of COVID-19 nanoparticle vaccine REVC-128 provides protection against SARS-CoV-2 challenge at two weeks post immunization.
Gu M, Torres JL, Li Y, Ry AV, Greenhouse J, Wallace S, Chiang CI, Pessaint L, Jackson AM, Porto M, Kar S, Li Y, Ward AB, Wang Y.
October 8 2021 JCI Insight. Human antibody recognition of H7N9 influenza virus HA following natural infection.
Gilchuk IM, Bangaru S, Kose N, Bombardi RG, Trivette A, Li S, Turner HL, Carnahan RH, Ward AB, Crowe JE Jr.
August 25 2021 PLoS Pathog. Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.
van Schooten J, van Haaren MM, Li H, McCoy LE, Havenar-Daughton C, Cottrell CA, Burger JA, van der Woude P, Helgers LC, Tomris I, Labranche CC, Montefiori DC, Ward AB, Burton DR, Moore JP, Sanders RW, Crotty S, Shaw GM, van Gils MJ.
August 10 2021 Nat Commun. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Antanasijevic A, Sewall LM, Cottrell CA, Carnathan DG, Jimenez LE, Ngo JT, Silverman JB, Groschel B, Georgeson E, Bhiman J, Bastidas R, LaBranche C, Allen JD, Copps J, Perrett HR, Rantalainen K, Cannac F, Yang YR, de la Peña AT, Rocha RF, Berndsen ZT, Baker D, King NP, Sanders RW, Moore JP, Crotty S, Crispin M, Montefiori DC, Burton DR, Schief WR, Silvestri G, Ward AB.
August 10 2021 J Virol Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein
van Haaren MM, McCoy LE, Torres JL, Lee W, Cottrell CA, Copps JL, van der Woude P, Yasmeen A, de Taeye SW, Torrents de la Peña A, Moore JP, Burton DR, Klasse PJ, Ward AB, Sanders RW, van Gils MJ.
August 2 2021 J Clin Invest. Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr.
July 28 2021 Sci Adv. Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.
Turner HL, Andrabi R, Cottrell CA, Richey ST, Song G, Callaghan S, Anzanello F, Moyer TJ, Abraham W, Melo M, Silva M, Scaringi N, Rakasz EG, Sattentau QJ, Irvine DJ, Burton DR, Ward AB.
July 27 2021 mBio Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner.
Amanat F, Strohmeier S, Lee WH, Bangaru S, Ward AB, Coughlan L, Krammer F.
July 13 2021 Cell Rep. Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects.
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June 2 2021 Sci Transl Med. First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes.
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May 25 2021 Cell Rep Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells.
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May 20 2021 Science Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
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May 19 2021 Nat Commun. Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection.
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May 12 2021 Cell Host Microbe A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection.
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May 11 2021 Nat Commun. Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines.
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April 13 2021 Cell Rep Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
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April 7 2021 PLoS Pathog. Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.
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April 6 2021 Cell Rep. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.
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March 22 2021 PLoS Pathog. A cross-neutralizing antibody between HIV-1 and influenza virus.
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February 23 2021 Proc Natl Acad Sci U S A. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.
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February 23 2021 Cell Extremely potent human monoclonal antibodies from COVID-19 convalescent patients.
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February 9 2021 NPJ Vaccines Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles
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February 8 2021 PLoS Pathog The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
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February 8 2021 PLoS Pathog. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins.
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February 3 2021 J Virol Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization.
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January 26 2021 Cell Rep Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination.
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January 26 2021 Cell Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
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January 13 2021 Elife High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post HIV Env trimer vaccination.
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December 22 2020 Structure Structure and immune recognition of the porcine epidemic diarrhea virus spike protein.
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December 18 2020 iScience Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail.
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December 4 2020 PLoS Pathog. A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.
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November 25 2020 Nature Discoveries in structure and physiology of mechanically activated ion channels.
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November 24 2020 Cell Rep. A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide
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November 21 2020 Immunity Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.
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October 22 2020 Proc Natl Acad Sci U S A. Visualization of the HIV-1 Env glycan shield across scales.
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October 20 2020 Science Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
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October 17 2020 Immunity Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.
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September 30 2020 J Virol. Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers.
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September 29 2020 Cell Rep. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain.
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September 14 2020 Cell SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2
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September 8 2020 Cell Rep. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques.
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August 31 2020 PLoS Pathog Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
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August 31 2020 Nature Human germinal centres engage memory and naive B cells after influenza vaccination.
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August 11 2020 PLoS Pathog Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.
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August 5 2020 NPJ Vaccines Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations
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August 4 2020 J Clin Invest Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
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July 25 2020 Protein Sci. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells.
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July 15 2020 Vaccines A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice.
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July 13 2020 Proc Natl Acad Sci U S A. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans.
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June 15 2020 Science Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
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June 5 2020 Sci Adv. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite.
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May 27 2020 Nat Commun. Vulnerabilities in coronavirus glycan shields despite extensive glycosylation.
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May 27 2020 Sci Adv. Structural basis of broad HIV neutralization by a vaccine-induced cow antibody.
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May 19 2020 Structure Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions.
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April 28 2020 Cell Rep HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.
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April 22 2020 Curr Opin Immunol. Innovations in structure-based antigen design and immune monitoring for next generation vaccines
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March 17 2020 Cell Rep. Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines.
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March 9 2020 PLoS Pathog Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
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February 17 2020 Nat Med Engineered immunogen binding to alum adjuvant enhances humoral immunity.
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February 3 2020 Immunity Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
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January 15 2020 J Virol. Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits.
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December 27 2019 J Mol Biol Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein.
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December 18 2019 J Virol Neutralizing antibody induction by HIV-1 Envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin.
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November 26 2019 Nat Commun An MPER antibody neutralizes HIV-1 using germline features shared among donors.
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November 25 2019 Cell Host Microbe Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
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November 25 2019 Cell Host Microbe Influenza H7N9 Virus Neuraminidase-Specific Human Monoclonal Antibodies Inhibit Viral Egress and Protect from Lethal Influenza Infection in Mice.
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November 7 2019 PLoS Pathog Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins.
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October 31 2019 Science A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
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October 16 2019 J Virol SOS and IP modifications predominantly affect the yield but not other properties of SOSIP.664 HIV-1 Env glycoprotein trimers.
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September 24 2019 Cell Rep Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD.
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September 19 2019 Nat Commun Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
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July 23 2019 Proc Natl Acad Sci U S A Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics.
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July 15 2019 PLoS Pathog. Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.
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July 2 2019 MBio Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization.
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June 12 2019 Cell Host Microbe Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
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June 3 2019 Nat Struct Mol Biol Structures of the otopetrin proton channels Otop1 and Otop3.
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May 29 2019 Nat Commun Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
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October 20 2018 Sci Adv Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.
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July 10 2018 Nat Commun A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
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June 20 2018 Nat Microbiol Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.
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May 16 2018 Nat Commun Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.
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March 4 2016 Science Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
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February 22 2013 Science Biochemistry. Integrative structural biology.
Ward AB, Sali A, Wilson IA
October 18 2012 Cell Host Microbe A Blueprint for HIV Vaccine Discovery.
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September 27 2012 Nature Cross-neutralization of influenza A viruses mediated by a single antibody loop.
Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA
September 14 2012 Science Highly conserved protective epitopes on influenza B viruses.
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July 13 2012 J Biol Chem Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers.
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November 25 2011 Science A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
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November 23 2011 Nature Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
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