Random Structure - EMD-9065
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Recent Publications
Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.
Freyn AW, Han J, Guthmiller JJ, Bailey MJ, Neu K, Turner HL, Rosado VC, Chromikova V, Huang M, Strohmeier S, Liu STH, Simon V, Krammer F, Ward AB, Palese P, Wilson PC, Nachbagauer R.
Proc Natl Acad Sci U S A., Feb. 23, 2021, PMID:33593910
Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles
Brouwer PJM, Antanasijevic A, de Gast M, Allen JD, Bijl TPL, Yasmeen A, Ravichandran R, Burger JA, Ozorowski G, Torres JL, LaBranche C, Montefiori DC, Ringe RP, van Gils MJ, Moore JP, Klasse PJ, Crispin M, King NP, Ward AB, Sanders RW.
NPJ Vaccines, Feb. 9, 2021, PMID:33563983
The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
Charles TP, Burton SL, Arunachalam PS, Cottrell CA, Sewall LM, Bollimpelli VS, Gangadhara S, Dey AK, Ward AB, Shaw GM, Hunter E, Amara RR, Pulendran B, van Gils MJ, Derdeyn CA.
PLoS Pathog, Feb. 8, 2021, PMID:33556148
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins.
Bouwman KM, Tomris I, Turner HL, van der Woude R, Shamorkina TM, Bosman GP, Rockx B, Herfst S, Snijder J, Haagmans BL, Ward AB, Boons GJ, de Vries RP.
PLoS Pathog., Feb. 8, 2021, PMID:33556147
Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization.
Wang Y, Howell KA, Brannan J, Agans KN, Turner HL, Wirchnianski AS, Kailasan S, Fusco M, Galkin A, Chiang CI, Zhao X, Saphire EO, Chandran K, Ward AB, Dye JM, Aman MJ, Geisbert TW, Li Y.
J Virol, Feb. 3, 2021, PMID:33536172
Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination.
Han J, Schmitz AJ, Richey ST, Dai YN, Turner HL, Mohammed BM, Fremont DH, Ellebedy AH, Ward AB.
Cell Rep, Jan. 26, 2021, PMID:33503432
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
Brouwer PJM, Brinkkemper M, Maisonnasse P, Dereuddre-Bosquet N, Grobben M, Claireaux M, de Gast M, Marlin R, Chesnais V, Diry S, Allen JD, Watanabe Y, Giezen JM, Kerster G, Turner HL, van der Straten K, van der Linden CA, Aldon Y, Naninck T, Bontjer I, Burger JA, Poniman M, Mykytyn AZ, Okba NMA, Schermer EE, van Breemen MJ, Ravichandran R, Caniels TG, van Schooten J, Kahlaoui N, Contreras V, Lemaître J, Chapon C, Fang RHT, Villaudy J, Sliepen K, van der Velden YU, Haagmans BL, de Bree GJ, Ginoux E, Ward AB, Crispin M, King NP, van der Werf S, van Gils MJ, Le Grand R, Sanders RW.
Cell, Jan. 26, 2021, PMID:33577765
High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post HIV Env trimer vaccination.
Dingens AS, Pratap P, Malone KD, Hilton SK, Ketas T, Cottrell CA, Overbaugh JM, Moore JP, Klasse PJ, Ward AB, Bloom JD.
Elife, Jan. 13, 2021, PMID:33438580
Structure and immune recognition of the porcine epidemic diarrhea virus spike protein.
Kirchdoerfer RN, Bhandari M, Martini O, Sewall LM, Bangaru S, Yoon KJ, Ward AB
Structure, Dec. 22, 2020, PMID:33378641
Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail.
Chakraborty S, Berndsen ZT, Hengartner NW, Korber BT, Ward AB, Gnanakaran S.
iScience, Dec. 18, 2020, PMID:33319171