Random Structure - EMD-7577
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Recent Publications
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog, Aug. 31, 2020, PMID:32866207
Human germinal centres engage memory and naive B cells after influenza vaccination.
Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Alsoussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Richey ST, Haile A, Yang YR, Klebert MK, Suessen T, Teefey S, Presti RM, Krammer F, Kleinstein SH, Ward AB, Ellebedy AH.
Nature, Aug. 31, 2020, PMID:32866963
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB.
PLoS Pathog, Aug. 11, 2020, PMID:32780770
Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations
Martin JT, Cottrell CA, Antanasijevic A, Carnathan DG, Cossette BJ, Enemuo CA, Gebru EH, Choe Y, Viviano F, Fischinger S, Tokatlian T, Cirelli KM, Ueda G, Copps J, Schiffner T, Menis S, Alter G, Schief WR, Crotty S, King NP, Baker D, Silvestri G, Ward AB, Irvine DJ.
NPJ Vaccines, Aug. 5, 2020, PMID:32802411
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.
Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D.
Elife., Aug. 4, 2020, PMID:32748788
Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
Dong J, Gilchuk I, Li S, Irving R, Goff MT, Turner HL, Ward AB, Carnahan RH, Crowe JE Jr.
J Clin Invest, Aug. 4, 2020, PMID:32749241
Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells.
van der Woude R, Turner HL, Tomris I, Bouwman KM, Ward AB, de Vries RP.
Protein Sci., July 25, 2020, PMID:32710576
A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice.
Thrane S, Aves KL, Uddbäck IEM, Janitzek CM, Han J, Yang YR, Ward AB, Theander TG, Nielsen MA, Salanti A, Thomsen AR, Christensen JP, Sander AF.
Vaccines, July 15, 2020, PMID:32679905
Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans.
Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R.
Proc Natl Acad Sci U S A., July 13, 2020, PMID:32661157
Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers.
Carnathan DG, Kaushik K, Ellebedy AH, Enemuo CA, Gebru EH, Dhadvai P, Rasheed MAU, Pauthner MG, Ozorowski G, Ahmed R, Burton DR, Ward AB, Silvestri G, Crotty S, Locci M.
Front Immunol, June 16, 2020, PMID:32612608