A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers.
Chaturbhuj DN, Sliepen K, Cupo A, Steinberg B, Kazimierczyk S, Munawar T, Kramer K, Yasmeen A, Andrade TG, Lee W-H, van der Maas L, Gibson G, Feliciano O, Del Moral Sanchez I, Schermer E, Bronson R, Benner A, Prabhakaran M, Mason R, Klasse PJ, Ward AB, Ozorowski G, Sanders RW, Moore JP.
|
J Virol
|
Aug. 27, 2025
|
|
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Turner L, Nunez de Villavicencio Diaz T, Raghavan SSR, Kana IH, Lyimo E, Reitzel C, Wang CW, Berube E, Jensen RW, Loeffler JR, Fernández-Quintero ML, Theander TG, Lusingu JPA, Le Bihan T, Han X, Minja DTR, Ward AB, Ma B, Lavstsen T.
|
Proc Natl Acad Sci U S A
|
Aug. 26, 2025
|
|
HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Ma KM, Sutton HJ, Pratap PP, Steichen JM, Carnathan D, Quinn J, Kalyuzhniy O, Liguori A, Agrawal S, Baboo S, Madden P, Cottrell CA, Willis JR, Lee JH, Landais E, Hu X, Ramezani-Rad P, Ozorowski G, Lewis VR, Diedrich JK, Zhou X, Altheide TK, Phelps N, Georgeson E, Alavi NB, Lu D, Eskandarzadeh S, Kubitz M, Adachi Y, Mullen TM, Silva M, Melo MB, Himansu S, Irvine DJ, Burton DR, Yates JR 3rd, Paulson JC, Sok D, Wilson IA, Silvestri G, Ward AB, Crotty S, Schief WR.
|
Sci Immunol
|
Aug. 22, 2025
|
|
Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.
Bale S, Gustchina E, Guenaga J, Ayala V, Lee WH, Ozorowski G, Whitney S, Wilson R, Baboo S, Diedrich JK, Doyle ED, Hudacik L, Ben-Akiva E, Rodrigues KA, Irvine DJ, Yates JR 3rd, Paulson JC, Ward AB, Fouts T, Wyatt RT.
|
NPJ Vaccines
|
Aug. 20, 2025
|
|
Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Pratap PP, Cottrell CA, Quinn J, Carnathan DG, Bader DLV, Tran AS, Enemuo CA, Ngo JT, Richey ST, Gao H, Shen X, Greene KM, Hurtado J, Michaels KK, Ben-Akiva E, Lemnios A, Melo MB, Allen JD, Ozorowski G, Crispin M, Briney B, Montefiori D, Silvestri G, Irvine DJ, Crotty S, Ward AB.
|
NPJ Vaccines
|
Aug. 20, 2025
|
|
Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM.
Ferguson JA, Raghavan SSR, Alzua GP, Bhavsar D, Huang J, Rodriguez AJ, Torres JL, Bottermann M, Han J, Krammer F, Batista FD, Ward AB.
|
Sci Adv
|
Aug. 15, 2025
|
|
A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins.
Puente-Massaguer E, Andrade TG, Scherm MJ, Vasilev K, Abozeid H, Rodriguez AJ, Yueh J, Bhavsar D, Campbell JD, Yu D, Webby RJ, Kawaoka Y, Neumann G, Han J, Ward AB, Krammer F.
|
bioRxiv
|
Aug. 14, 2025
|
|
Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3.
Jo G, Yamayoshi S, Ma KM, Swanson O, Torres JL, Ferguson JA, Fernández-Quintero ML, Huang J, Copps J, Rodriguez AJ, Steichen JM, Kawaoka Y, Han J, Ward AB.
|
Nat Commun
|
Aug. 1, 2025
|
|
Corrigendum to Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr.
|
J Clin Invest
|
Aug. 1, 2025
|
|
Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K, Turroja M, Desrosiers A, Bethony J, Malkin E, Liesdek MH, van der Veen A, Klouwens M, Snitselaar JL, Bouhuijs JH, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran Tehrani Z, Benner A, Ramaswami M, Duff MO, Liu YW, Sato AH, Kim JY, Baken IJL, Mendes Silva C, Bijl TPL, van Rijswijk J, Burger JA, Cupo A, Yasmeen A, Phulera S, Lee WH, Randall KN Jr, Zhang S, Corcoran MM, Regadas I, Sullivan AC, Brown DM, Bohl JA, Greene KM, Gao H, Yates NL, Sawant S, Prins JM, Kootstra NA, Kaminsky SM, Barin B, Rahaman F, Meller M, Philiponis V, Laufer DS, Lombardo A, Mwoga L, Shotorbani S, Holman D, Koup RA, Klasse PJ, Karlsson Hedestam GB, Tomaras GD, van Gils MJ, Montefiori DC, McDermott AB, Hyrien O, Moore JP, Wilson IA, Ward AB, Diemert DJ, de Bree GJ, Andrews SF, Caskey M, Sanders RW.
|
Science
|
July 31, 2025
|
|
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.
Willis JR, Prabhakaran M, Muthui M, Naidoo A, Sincomb T, Wu W, Cottrell CA, Landais E, deCamp AC, Keshavarzi NR, Kalyuzhniy O, Lee JH, Murungi LM, Ogonda WA, Yates NL, Corcoran MM, Phulera S, Musando J, Tsai A, Lemire G, Sein Y, Muteti M, Alamuri P, Bohl JA, Holman D, Himansu S, Leav B, Reuter C, Lin LA, Ding B, He C, Straus WL, MacPhee KJ, Regadas I, Nyabundi DV, Chirchir R, Anzala O, Kimotho JN, Kibet C, Greene K, Gao H, Beatman E, Benson K, Laddy D, Brown DM, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran-Tehrani Z, Benner A, Ramaswami M, Lu D, Alavi N, Amirzehni S, Kubitz M, Tingle R, Georgeson E, Phelps N, Adachi Y, Liguori A, Flynn C, McKenney K, Zhou X, Owuor DC, Owuor SA, Kim SY, Duff M, Kim JY, Gibson G, Baboo S, Diedrich J, Schiffner T, Shields M, Matsoso M, Santos J, Syvertsen K, Kennedy A, Schroeter M, Vekemans J, Yates JR 3rd, Paulson JC, Hyrien O, McDermott AB, Maenetje P, Nyombayire J, Karita E, Ingabire R, Edward V, Muturi-Kioi V, Maenza J, Shapiro AE, McElrath MJ, Edupuganti S, Taylor BS, Diemert D, Ozorowski G, Koup RA, Montefiori D, Ward AB, Karlsson Hedestam GB, Tomaras G, Hunt DJ, Muema D, Sok D, Laufer DS, Andrews SF, Nduati EW, Schief WR.
|
Science
|
July 31, 2025
|
|
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
Parks KR, Moodie Z, Allen MA, Yen C, Furch BD, MacPhee KJ, Ozorowski G, Heptinstall J, Hahn WO, Zheng Z, Lu H, Grant S, Domin E, Duff MO, Seese A, Marini-Macouzet C, Ballweber-Fleming L, Lee WH, Cottrell CA, Liguori A, Georgeson E, Alavi N, Kubitz M, Phelps N, Seaton KE, Cohen KW, Anderson MA, Mondal K, Laufer DS, Kublin JG, Ward AB, Hyrien O, De Rosa SC, Himansu S, Leav B, Reuter C, Tomaras GD, Montefiori D, Walsh SR, Frank I, Sobieszczyk ME, Goepfert PA, Stephenson KE, Baden LR, Van Tieu H, Keefer MC, Clark J, Riddler SA, Schief WR, McElrath MJ.
|
Sci Transl Med
|
July 30, 2025
|
|
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.
Ramezani-Rad P, Cottrell CA, Marina-Zárate E, Liguori A, Landais E, Torres JL, Myers A, Lee JH, Baboo S, Flynn C, McKenney K, Salcedo E, Zhou X, Kalyuzhniy O, Georgeson E, Phelps N, Lu D, Eskandarzadeh S, Menis S, Kubitz M, Groschel B, Alavi N, Jackson AM, Lee WH, Tran AS, Ben-Akiva E, Kaczmarek Michaels K, Diedrich JK, Enemuo CA, Lewis V, Pradhan A, Kasturi SP, Schiffner T, Steichen JM, Carnathan DG, Himansu S, Yates JR 3rd, Paulson JC, Ozorowski G, Irvine DJ, Silvestri G, Sok D, Ward AB, Crotty S, Schief WR.
|
Sci Transl Med
|
July 30, 2025
|
|
De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells.
Johansen KH, Wolff DS, Scapolo B, Fernández-Quintero ML, Risager Christensen C, Loeffler JR, Rivera-de-Torre E, Overath MD, Kjærgaard Munk K, Morell O, Viuff MC, Lacunza I, Damm Englund AT, Due M, Gharpure A, Forli S, Rodriguez Pardo C, Tamhane T, Qingjie Andersen E, Haldrup Björnsson K, Fernandes JS, Voss LF, Thumtecho S, Ward AB, Ormhøj M, Reker Hadrup S, Jenkins TP.
|
Science
|
July 24, 2025
|
|
The HIV-1 envelope glycoprotein: structure, function and interactions with neutralizing antibodies.
Klasse PJ, Sanders RW, Ward AB, Wilson IA, Moore JP.
|
Nat Rev Microbiol
|
July 23, 2025
|
|
Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines.
Bangaru S, Jackson AM, Copps J, Fernández-Quintero ML, Torres JL, Richey ST, Nogal B, Sewall LM, Torrents de la Peña A, Rehman A, Guebre-Xabier M, Girard B, Das R, Corbett-Helaire KS, Seder RA, Graham BS, Edwards DK, Patel N, Smith G, Ward AB.
|
Cell Rep
|
July 22, 2025
|
|
Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Song G, Yuan M, Liu H, Capozzola T, Lin RN, Torres JL, He WT, Musharrafieh R, Dueker K, Zhou P, Callaghan S, Mishra N, Yong P, Anzanello F, Avillion G, Vo AL, Li X, Zhang Y, Makhdoomi M, Feng Z, Zhu X, Peng L, Nemazee D, Safonova Y, Briney B, Ward AB, Burton DR, Wilson IA, Andrabi R.
|
Cell Rep
|
July 22, 2025
|
|
Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein.
Feng Z, Huang J, Baboo S, Diedrich JK, Bangaru S, Paulson JC, Yates JR 3rd, Yuan M, Wilson IA, Ward AB.
|
Cell Rep
|
July 22, 2025
|
|
Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V(H)Hs discovered using a consensus antigen.
Damsbo A, Burlet NJ, Fernández-Quintero ML, Benard-Valle M, Overath MD, Guadarrama-Martínez A, Vlamynck A, Bisbo I, Villalobos C, Tulika T, Alagón A, Loeffler JR, Ward AB, Boddum K, Morth JP, Rivera-de-Torre E, Laustsen AH.
|
Commun Chem
|
July 19, 2025
|
|
Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance.
Gilchuk IM, Dong J, Irving RP, Buchman CD, Armstrong E, Turner HL, Li S, Ward AB, Carnahan RH, Crowe JE Jr.
|
JCI Insight
|
July 8, 2025
|
|