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A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris.
Bai J, Swartz DJ, Protasevich II, Brouillette CG, Harrell PM, Hildebrandt E, Gasser B, Mattanovich D, Ward A, Chang G, Urbatsch IL.
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PLoS One
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Jan. 1, 2011
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Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase.
Glaves JP, Fisher L, Ward A, Young HS.
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Methods Enzymol
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Jan. 1, 2010
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Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1.
Gutmann DA, Ward A, Urbatsch IL, Chang G, van Veen HW.
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Trends Biochem Sci
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Jan. 1, 2010
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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.
Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G.
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Science
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March 27, 2009
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Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA.
Ward A, Mulligan S, Carragher B, Chang G, Milligan RA.
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J Struct Biol
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March 1, 2009
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Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles.
Littlefield KP, Ward AB, Chappie JS, Reedy MK, Bernstein SI, Milligan RA, Reedy MC.
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J Mol Biol
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Sept. 5, 2008
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Flexibility in the ABC transporter MsbA: Alternating access with a twist.
Ward A, Reyes CL, Yu J, Roth CB, Chang G.
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Proc Natl Acad Sci U S A
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Nov. 27, 2007
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Designing facial amphiphiles for the stabilization of integral membrane proteins.
Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang G.
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Angew Chem Int Ed Engl
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Jan. 1, 2007
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The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux.
Reyes CL, Ward A, Yu J, Chang G.
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FEBS Lett
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Feb. 13, 2006
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