Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Turner L, Nunez de Villavicencio Diaz T, Raghavan SSR, Kana IH, Lyimo E, Reitzel C, Wang CW, Berube E, Jensen RW, Loeffler JR, Fernández-Quintero ML, Theander TG, Lusingu JPA, Le Bihan T, Han X, Minja DTR, Ward AB, Ma B, Lavstsen T.
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Proc Natl Acad Sci U S A
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Aug. 26, 2025
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Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.
Bale S, Gustchina E, Guenaga J, Ayala V, Lee WH, Ozorowski G, Whitney S, Wilson R, Baboo S, Diedrich JK, Doyle ED, Hudacik L, Ben-Akiva E, Rodrigues KA, Irvine DJ, Yates JR 3rd, Paulson JC, Ward AB, Fouts T, Wyatt RT.
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NPJ Vaccines
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Aug. 20, 2025
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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Pratap PP, Cottrell CA, Quinn J, Carnathan DG, Bader DLV, Tran AS, Enemuo CA, Ngo JT, Richey ST, Gao H, Shen X, Greene KM, Hurtado J, Michaels KK, Ben-Akiva E, Lemnios A, Melo MB, Allen JD, Ozorowski G, Crispin M, Briney B, Montefiori D, Silvestri G, Irvine DJ, Crotty S, Ward AB.
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NPJ Vaccines
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Aug. 20, 2025
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Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM.
Ferguson JA, Raghavan SSR, Alzua GP, Bhavsar D, Huang J, Rodriguez AJ, Torres JL, Bottermann M, Han J, Krammer F, Batista FD, Ward AB.
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Sci Adv
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Aug. 15, 2025
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A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins.
Puente-Massaguer E, Andrade TG, Scherm MJ, Vasilev K, Abozeid H, Rodriguez AJ, Yueh J, Bhavsar D, Campbell JD, Yu D, Webby RJ, Kawaoka Y, Neumann G, Han J, Ward AB, Krammer F.
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bioRxiv
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Aug. 14, 2025
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Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3.
Jo G, Yamayoshi S, Ma KM, Swanson O, Torres JL, Ferguson JA, Fernández-Quintero ML, Huang J, Copps J, Rodriguez AJ, Steichen JM, Kawaoka Y, Han J, Ward AB.
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Nat Commun
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Aug. 1, 2025
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Corrigendum to Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr.
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J Clin Invest
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Aug. 1, 2025
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Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K, Turroja M, Desrosiers A, Bethony J, Malkin E, Liesdek MH, van der Veen A, Klouwens M, Snitselaar JL, Bouhuijs JH, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran Tehrani Z, Benner A, Ramaswami M, Duff MO, Liu YW, Sato AH, Kim JY, Baken IJL, Mendes Silva C, Bijl TPL, van Rijswijk J, Burger JA, Cupo A, Yasmeen A, Phulera S, Lee WH, Randall KN Jr, Zhang S, Corcoran MM, Regadas I, Sullivan AC, Brown DM, Bohl JA, Greene KM, Gao H, Yates NL, Sawant S, Prins JM, Kootstra NA, Kaminsky SM, Barin B, Rahaman F, Meller M, Philiponis V, Laufer DS, Lombardo A, Mwoga L, Shotorbani S, Holman D, Koup RA, Klasse PJ, Karlsson Hedestam GB, Tomaras GD, van Gils MJ, Montefiori DC, McDermott AB, Hyrien O, Moore JP, Wilson IA, Ward AB, Diemert DJ, de Bree GJ, Andrews SF, Caskey M, Sanders RW.
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Science
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July 31, 2025
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Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.
Willis JR, Prabhakaran M, Muthui M, Naidoo A, Sincomb T, Wu W, Cottrell CA, Landais E, deCamp AC, Keshavarzi NR, Kalyuzhniy O, Lee JH, Murungi LM, Ogonda WA, Yates NL, Corcoran MM, Phulera S, Musando J, Tsai A, Lemire G, Sein Y, Muteti M, Alamuri P, Bohl JA, Holman D, Himansu S, Leav B, Reuter C, Lin LA, Ding B, He C, Straus WL, MacPhee KJ, Regadas I, Nyabundi DV, Chirchir R, Anzala O, Kimotho JN, Kibet C, Greene K, Gao H, Beatman E, Benson K, Laddy D, Brown DM, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran-Tehrani Z, Benner A, Ramaswami M, Lu D, Alavi N, Amirzehni S, Kubitz M, Tingle R, Georgeson E, Phelps N, Adachi Y, Liguori A, Flynn C, McKenney K, Zhou X, Owuor DC, Owuor SA, Kim SY, Duff M, Kim JY, Gibson G, Baboo S, Diedrich J, Schiffner T, Shields M, Matsoso M, Santos J, Syvertsen K, Kennedy A, Schroeter M, Vekemans J, Yates JR 3rd, Paulson JC, Hyrien O, McDermott AB, Maenetje P, Nyombayire J, Karita E, Ingabire R, Edward V, Muturi-Kioi V, Maenza J, Shapiro AE, McElrath MJ, Edupuganti S, Taylor BS, Diemert D, Ozorowski G, Koup RA, Montefiori D, Ward AB, Karlsson Hedestam GB, Tomaras G, Hunt DJ, Muema D, Sok D, Laufer DS, Andrews SF, Nduati EW, Schief WR.
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Science
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July 31, 2025
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Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines.
Bangaru S, Jackson AM, Copps J, Fernández-Quintero ML, Torres JL, Richey ST, Nogal B, Sewall LM, Torrents de la Peña A, Rehman A, Guebre-Xabier M, Girard B, Das R, Corbett-Helaire KS, Seder RA, Graham BS, Edwards DK, Patel N, Smith G, Ward AB.
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Cell Rep
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July 22, 2025
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Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Song G, Yuan M, Liu H, Capozzola T, Lin RN, Torres JL, He WT, Musharrafieh R, Dueker K, Zhou P, Callaghan S, Mishra N, Yong P, Anzanello F, Avillion G, Vo AL, Li X, Zhang Y, Makhdoomi M, Feng Z, Zhu X, Peng L, Nemazee D, Safonova Y, Briney B, Ward AB, Burton DR, Wilson IA, Andrabi R.
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Cell Rep
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July 22, 2025
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Structural and functional insights into the evolution of SARS-CoV-2 KP.3.1.1 spike protein.
Feng Z, Huang J, Baboo S, Diedrich JK, Bangaru S, Paulson JC, Yates JR 3rd, Yuan M, Wilson IA, Ward AB.
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Cell Rep
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July 22, 2025
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Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance.
Gilchuk IM, Dong J, Irving RP, Buchman CD, Armstrong E, Turner HL, Li S, Ward AB, Carnahan RH, Crowe JE Jr.
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JCI Insight
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July 8, 2025
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Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion.
Rodrigues KA, Zhang YJ, Lam J, Aung A, Morgan DM, Romanov A, Maiorino L, Yousefpour P, Gibson G, Ozorowski G, Gregory JR, Amlashi P, Van R, Buckley M, Ward AB, Schief WR, Love JC, Irvine DJ.
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Sci Transl Med
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June 18, 2025
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CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse.
Ross P, Cid T, Fernández Quintero M, Loeffler J, Fatima H, Leaman DP, Matthias J, Spencer K, Zwick MB, Henderson SC, Ward AB, Mace EM, Murin CD.
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J Immunol
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June 16, 2025
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Antigenic and EM characterization of the Chiron experimental hepatitis C virus vaccine.
Hung SH, Torres JL, Chen F, Giang E, Ward AB, Law M.
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Vaccine
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June 11, 2025
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Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.
Marini-Rapoport O, Andrieux L, Keswani T, Zong G, Duchen D, Yaari G, Min J, Lytle IR, Rosenberg AF, Fucile C, Kobie JJ, Piepenbrink MS, Sun T, Martin VM, Yuan Q, Shreffler WG, Seppo AE, Järvinen KM, Loeffler JR, Ward AB, Kleinstein SH, Pedersen LC, Fernández-Quintero ML, Mueller GA, Patil SU.
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Sci Transl Med
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June 11, 2025
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer.
Schleich FA, Bale S, Guenaga J, Ozorowski G, Àdori M, Lin X, Castro Dopico X, Wilson R, Chernyshev M, Cotgreave AT, Mandolesi M, Cluff J, Doyle ED, Sewall LM, Lee WH, Zhang S, O'Dell S, Healy BS, Lim D, Lewis VR, Ben-Akiva E, Irvine DJ, Doria-Rose NA, Corcoran M, Carnathan D, Silvestri G, Wilson IA, Ward AB, Karlsson Hedestam GB, Wyatt RT.
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Immunity
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June 10, 2025
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