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Virus glycoprotein nanodisc platform for vaccine analytics.
Rantalainen K, Liguori A, Ozorowski G, Flynn C, Steichen JM, Swanson OM, Madden PJ, Baboo S, Phulera S, Gharpure A, Lu D, Kalyuzhniy O, Skog P, Terada S, Shil M, Diedrich JK, Georgeson E, Tingle R, Eskandarzadeh S, Lee WH, Alavi N, Goodwin D, Kubitz M, Amirzehni S, Himansu S, Sok D, Lee JH, Yates JR 3rd, Paulson JC, Crotty S, Schiffner T, Ward AB, Schief WR.
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Nat Commun
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Feb. 10, 2026
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Cryo-EM structures of antibodies elicited by germline-targeting HIV MPER epitope scaffolds.
Huang J, Swanson OM, Rantalainen K, Fernández-Quintero ML, Loeffler JR, Tingle R, Georgeson E, Phelps N, Ozorowski G, Schiffner T, Schief WR, Ward AB.
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Cell Rep
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Jan. 27, 2026
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Structural and functional characterization of the antigenicity of influenza A virus hemagglutinin subtype H15.
Bhavsar D, León AN, Hsu WL, Puente-Massaguer E, Ferguson JA, Han J, Wilson P, Ward AB, Krammer F.
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Cell Rep
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Jan. 27, 2026
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An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins.
Puente-Massaguer E, Galdino Andrade T, Scherm MJ, Vasilev K, Abozeid H, Rodriguez AJ, Yueh J, Bhavsar D, Campbell JD, Yu D, Webby RJ, Kawaoka Y, Neumann G, Han J, Ward AB, Krammer F.
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Nat Commun
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Jan. 23, 2026
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Heterologous betacoronavirus spike immunization in nonhuman primates elicits cross-reactive antibodies that neutralize both sarbeco- and merbecoviruses.
Dueker K, Capozzola T, Feng Z, Lin RN, Hurtado J, Bangaru S, Yuan M, Beutler N, Garcia E, He WT, Callaghan S, Avillion G, Vo L, Li X, Torres JL, Musharrafieh R, Song G, Mishra N, Sharma P, Yong P, Anzanello F, Kaczmarek-Michaels K, Ben-Akiva E, Silva M, Melo M, Makhdoomi M, Westfall-Gomez E, Rinaldi W, Ferguson M, Safonova Y, Crotty S, Irvine DJ, Rogers T, Ward AB, Briney B, Wilson IA, Burton DR, Andrabi R.
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bioRxiv
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Jan. 23, 2026
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AlphaFold-RandomWalk and AlphaFold-Ensemble: Sampling Alternative Protein Conformations with Perturbed Versions of AlphaFold.
Taneja I, Llanos MA, Fernández-Quintero ML, Loeffler JR, Holcomb M, Ward AB, Forli S.
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J Chem Inf Model
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Jan. 12, 2026
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Human monoclonal antibodies that target clade 2.3.4.4b H5N1 hemagglutinin.
Alzua GP, León AN, Yellin T, Bhavsar D, Loganathan M, Bushfield K, Brouwer PJM, Rodriguez AJ, Jeevan T, Webby R, Marizzi C, Han J, Ward AB, Duty JA, Krammer F.
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Nat Commun
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Dec. 13, 2025
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Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification.
Lee YZ, Zhang YN, Newby ML, Ward G, Braz Gomes K, Auclair S, DesRoberts C, Allen JD, Ward AB, Stanfield RL, He L, Crispin M, Wilson IA, Zhu J.
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Nat Commun
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Dec. 12, 2025
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Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift.
de Paiva Froes Rocha R, Tomris I, Bowman CA, Stevens E, Kantorow J, Plitt CM, Peng W, Oeverdieck S, Galdino Andrade T, Ferguson JA, Jung DD, Marques RE, Herfst S, Snijder J, Chakraborty S, Torrents de la Peña A, Berndsen ZT, de Vries RP, Ward AB.
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Nat Commun
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Dec. 11, 2025
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Rethinking what pLDDT really tells us about protein flexibility.
Riccabona JR, Loeffler JR, Schoeder CT, Meiler J, Ward AB, Fernandez-Quintero M.
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Structure
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Dec. 4, 2025
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Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2.
Changrob S, Yasuhara A, Park S, Bangaru S, Li L, Troxell CA, Halfmann PJ, Erickson SA, Catanzaro NJ, Yuan M, Zhou P, Huang M, Wilbanks GD, McGrath JJC, Singh G, Nelson SA, Fu Y, Zheng NY, Carayannopoulos SM, Dugan HL, Shaw DG, Stamper CT, Madariaga MLL, Krammer F, Andrabi R, Burton DR, Ward AB, Wilson IA, Kawaoka Y, Wilson PC.
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J Exp Med
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Dec. 1, 2025
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Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins.
Wade J, Štrancar N, Fernández-Quintero ML, Siebenhaar S, Jansen T, Meier EPW, Jenkins TP, Bjørn SP, Nguyen GTT, Lomonte B, Gutiérrez JM, Sørensen CV, Loeffler JR, Paul A, Tulika T, Arnsdorf J, Schoffelen S, Lundquist EVS, Sørensen J, Ward AB, Voldborg BG, Bohn MF, Rivera-de-Torre E, Morth JP, Laustsen AH.
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MAbs
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Dec. 1, 2025
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HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial.
Reiss EIMM, van der Straten K, Graus LTM, Grobben M, Vlaming KE, van der Veen AIP, Liesdek MH, Ozorowski G, Corcoran M, Gao H, Greene KM, Yates NL, Sawant S, Kerster G, Burger JA, Schonherr S, Cheeseman HM, Evans A, McFarlane LR, Tran AS, Torres JL, Lin RN, Jo G, Tolazzi M, Mundsperger P, Katinger D, Cupo A, Moore JP, Hurks R, Vogt L, Soeters MR, Kootstra NA, Scarlatti G, Tomaras GD, Montefiori DC, Karlsson Hedestam GB, Ward AB, Klouwens M, de Jong MD, Prins JM, Claireaux M, Geijtenbeek TBH, Shattock RJ, van Gils MJ, Sanders RW, de Bree GJ.
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Nat Commun
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Nov. 21, 2025
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Human coronavirus HKU1 neutralization by glycan receptor mimicry.
Feng Z, Kose N, Moreira FR, Kimpel ALM, Copps J, Suryadevara N, Jackson DJ, Gern JE, Wilson IA, Li S, de Vries RP, Baric RS, Bangaru S, Crowe JE Jr, Ward AB.
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bioRxiv
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Nov. 7, 2025
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Data-optimal scaling of paired antibody language models.
Neyestanak MS, Burbach SM, Ng K, Gangavarapu P, Hurtado J, Magura J, Ismail N, Muema D, Ndung'u T, Ward AB, Briney B.
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bioRxiv
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Nov. 4, 2025
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The HIV-1 envelope glycoprotein: structure, function and interactions with neutralizing antibodies.
Klasse PJ, Sanders RW, Ward AB, Wilson IA, Moore JP.
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Nat Rev Microbiol
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Nov. 1, 2025
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Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites.
Ahmadi S, Burlet NJ, Benard-Valle M, Guadarrama-Martínez A, Kerwin S, Cardoso IA, Marriott AE, Edge RJ, Crittenden E, Neri-Castro E, Fernandez-Quintero ML, Nguyen GTT, O'Brien C, Wouters Y, Kalogeropoulos K, Thumtecho S, Ebersole TW, Dahl CH, Glegg-Sørensen EU, Jansen T, Boddum K, Manousaki E, Rivera-de-Torre E, Ward AB, Morth JP, Alagón A, Mackessy SP, Ainsworth S, Menzies SK, Casewell NR, Jenkins TP, Ljungars A, Laustsen AH.
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Nature
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Nov. 1, 2025
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Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates.
Akhtar A, Styles TM, Gu C, León AN, Tharp GK, Stokdyk K, Abbad A, Hirst C, Strohmeier S, Neumann G, Richey ST, Ferguson JA, Mala U, Ahmed H, Han J, Carreño JM, Davis CW, Antia R, Palese P, Ward AB, Kawaoka Y, Krammer F, Ahmed R, Amara RR.
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Nat Immunol
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Nov. 1, 2025
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Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody-viral glycoprotein complexes.
Sewall LM, de Paiva Froes Rocha R, Gibson G, Louie M, Xie Z, Bangaru S, Tran AS, Ozorowski G, Mohanty S, Beutler N, Rogers TF, Burton DR, Shaw AC, Batista FD, Chocarro Ruiz B, Torrents de la Peña A, Ward AB.
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Nat Biomed Eng
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Nov. 1, 2025
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Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site.
Wang L, Joseph J, Vasquez S, Wrapp D, Sheahan TP, Dzuvor CKO, Rosen O, Kirchdoerfer RN, Abiona OM, Hammond C, Shi W, Moak SP, Kong WP, Zhang Y, Eso MR, Brown AJ, Ward AB, Baric R, McLellan JS, Pierson TC, Mascola J, Graham BS, Yassine HM, Barnes CO, Corbett-Helaire KS.
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bioRxiv
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Oct. 30, 2025
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