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Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
Xie Z, Wang X, Yan Y, Steichen JM, Ma KM, Cottrell CA, Melzi E, Bottermann M, Villavicencio PM, Rantalainen K, Schiffner T, Warner JE, Weldon SR, Prum T, Ellis-Pugh JR, Torres JL, Jackson AM, Flynn CT, Ozorowski G, Himansu S, Carfi A, Ward AB, Nair U, Schief WR, Batista FD.
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Sci Immunol
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Oct. 17, 2025
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A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers.
Chaturbhuj DN, Sliepen K, Cupo A, Steinberg B, Kazimierczyk S, Munawar T, Kramer K, Yasmeen A, Andrade TG, Lee W-H, van der Maas L, Gibson G, Feliciano O, Del Moral Sanchez I, Schermer E, Bronson R, Benner A, Prabhakaran M, Mason R, Klasse PJ, Ward AB, Ozorowski G, Sanders RW, Moore JP.
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J Virol
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Sept. 23, 2025
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HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs.
Guenaga J, Adori M, Bale S, Phulera S, Zygouras I, Schleich FA, Dopico XC, Agrawal S, Ota M, Wilson R, Cluff J, Dzvelaia T, Mandolesi M, Walsh A, Melo MB, Verkoczy L, Irvine DJ, Corcoran M, Wilson IA, Carnathan D, Silvestri G, Ward AB, Ozorowski G, Karlsson Hedestam GB, Wyatt RT.
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bioRxiv
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Sept. 22, 2025
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GMP Manufacturing and Characterization of the HIV Booster Immunogen HxB2.WT.Core-C4b for Germline Targeting Vaccine Strategies.
Pallerla S, Kallur Siddaramaiah L, Mundsperger P, Katinger D, Fauland K, Kreismayr G, Weik R, Arslan O, Shen M, Ozorowski G, Lee WH, Ward AB, Baboo S, Diedrich JK, Yates JR 3rd, Paulson JC, Blumen T, Craig D, Swoyer R, Yuan M, Stamatatos L.
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Vaccines (Basel)
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Sept. 18, 2025
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Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.
Sangesland M, Li N, Tsybovsky Y, Rodgers MD, Han J, Rodriguez AJ, Ferguson JA, Henry AR, Smith SC, Roberts-Torres J, Gillespie RA, Liu C, Merriam JS, Stephens T, Williams C, Walker E, Corcoran M, Ravichandran M, Creanga A, Andrews SF, Pierson TC, Karlsson Hedestam GB, Schramm CA, Reed DS, Douek DC, Zhou T, Ward AB, Kanekiyo M.
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Sci Transl Med
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Sept. 10, 2025
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CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse.
Ross P, Cid T, Fernández Quintero M, Loeffler J, Fatima H, Leaman DP, Matthias J, Spencer K, Zwick MB, Henderson SC, Ward AB, Mace EM, Murin CD.
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J Immunol
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Sept. 1, 2025
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Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Turner L, Nunez de Villavicencio Diaz T, Raghavan SSR, Kana IH, Lyimo E, Reitzel C, Wang CW, Berube E, Jensen RW, Loeffler JR, Fernández-Quintero ML, Theander TG, Lusingu JPA, Le Bihan T, Han X, Minja DTR, Ward AB, Ma B, Lavstsen T.
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Proc Natl Acad Sci U S A
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Aug. 26, 2025
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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Ma KM, Sutton HJ, Pratap PP, Steichen JM, Carnathan D, Quinn J, Kalyuzhniy O, Liguori A, Agrawal S, Baboo S, Madden P, Cottrell CA, Willis JR, Lee JH, Landais E, Hu X, Ramezani-Rad P, Ozorowski G, Lewis VR, Diedrich JK, Zhou X, Altheide TK, Phelps N, Georgeson E, Alavi NB, Lu D, Eskandarzadeh S, Kubitz M, Adachi Y, Mullen TM, Silva M, Melo MB, Himansu S, Irvine DJ, Burton DR, Yates JR 3rd, Paulson JC, Sok D, Wilson IA, Silvestri G, Ward AB, Crotty S, Schief WR.
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Sci Immunol
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Aug. 22, 2025
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Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.
Bale S, Gustchina E, Guenaga J, Ayala V, Lee WH, Ozorowski G, Whitney S, Wilson R, Baboo S, Diedrich JK, Doyle ED, Hudacik L, Ben-Akiva E, Rodrigues KA, Irvine DJ, Yates JR 3rd, Paulson JC, Ward AB, Fouts T, Wyatt RT.
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NPJ Vaccines
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Aug. 20, 2025
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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Pratap PP, Cottrell CA, Quinn J, Carnathan DG, Bader DLV, Tran AS, Enemuo CA, Ngo JT, Richey ST, Gao H, Shen X, Greene KM, Hurtado J, Michaels KK, Ben-Akiva E, Lemnios A, Melo MB, Allen JD, Ozorowski G, Crispin M, Briney B, Montefiori D, Silvestri G, Irvine DJ, Crotty S, Ward AB.
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NPJ Vaccines
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Aug. 20, 2025
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CryoEM Structures of Antibodies Elicited by Germline-Targeting HIV MPER Epitope-Scaffolds.
Huang J, Swanson OM, Rantalainen K, Fernández-Quintero ML, Loeffler JR, Tingle R, Georgeson E, Phelps N, Ozorowski G, Schiffner T, Schief WR, Ward AB.
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bioRxiv
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Aug. 19, 2025
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Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM.
Ferguson JA, Raghavan SSR, Alzua GP, Bhavsar D, Huang J, Rodriguez AJ, Torres JL, Bottermann M, Han J, Krammer F, Batista FD, Ward AB.
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Sci Adv
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Aug. 15, 2025
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A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins.
Puente-Massaguer E, Andrade TG, Scherm MJ, Vasilev K, Abozeid H, Rodriguez AJ, Yueh J, Bhavsar D, Campbell JD, Yu D, Webby RJ, Kawaoka Y, Neumann G, Han J, Ward AB, Krammer F.
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bioRxiv
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Aug. 14, 2025
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Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3.
Jo G, Yamayoshi S, Ma KM, Swanson O, Torres JL, Ferguson JA, Fernández-Quintero ML, Huang J, Copps J, Rodriguez AJ, Steichen JM, Kawaoka Y, Han J, Ward AB.
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Nat Commun
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Aug. 1, 2025
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Corrigendum to Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr.
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J Clin Invest
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Aug. 1, 2025
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Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Caniels TG, Prabhakaran M, Ozorowski G, MacPhee KJ, Wu W, van der Straten K, Agrawal S, Derking R, Reiss EIMM, Millard K, Turroja M, Desrosiers A, Bethony J, Malkin E, Liesdek MH, van der Veen A, Klouwens M, Snitselaar JL, Bouhuijs JH, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran Tehrani Z, Benner A, Ramaswami M, Duff MO, Liu YW, Sato AH, Kim JY, Baken IJL, Mendes Silva C, Bijl TPL, van Rijswijk J, Burger JA, Cupo A, Yasmeen A, Phulera S, Lee WH, Randall KN Jr, Zhang S, Corcoran MM, Regadas I, Sullivan AC, Brown DM, Bohl JA, Greene KM, Gao H, Yates NL, Sawant S, Prins JM, Kootstra NA, Kaminsky SM, Barin B, Rahaman F, Meller M, Philiponis V, Laufer DS, Lombardo A, Mwoga L, Shotorbani S, Holman D, Koup RA, Klasse PJ, Karlsson Hedestam GB, Tomaras GD, van Gils MJ, Montefiori DC, McDermott AB, Hyrien O, Moore JP, Wilson IA, Ward AB, Diemert DJ, de Bree GJ, Andrews SF, Caskey M, Sanders RW.
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Science
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July 31, 2025
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Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.
Willis JR, Prabhakaran M, Muthui M, Naidoo A, Sincomb T, Wu W, Cottrell CA, Landais E, deCamp AC, Keshavarzi NR, Kalyuzhniy O, Lee JH, Murungi LM, Ogonda WA, Yates NL, Corcoran MM, Phulera S, Musando J, Tsai A, Lemire G, Sein Y, Muteti M, Alamuri P, Bohl JA, Holman D, Himansu S, Leav B, Reuter C, Lin LA, Ding B, He C, Straus WL, MacPhee KJ, Regadas I, Nyabundi DV, Chirchir R, Anzala O, Kimotho JN, Kibet C, Greene K, Gao H, Beatman E, Benson K, Laddy D, Brown DM, Bronson R, Jean-Baptiste J, Gajjala S, Rikhtegaran-Tehrani Z, Benner A, Ramaswami M, Lu D, Alavi N, Amirzehni S, Kubitz M, Tingle R, Georgeson E, Phelps N, Adachi Y, Liguori A, Flynn C, McKenney K, Zhou X, Owuor DC, Owuor SA, Kim SY, Duff M, Kim JY, Gibson G, Baboo S, Diedrich J, Schiffner T, Shields M, Matsoso M, Santos J, Syvertsen K, Kennedy A, Schroeter M, Vekemans J, Yates JR 3rd, Paulson JC, Hyrien O, McDermott AB, Maenetje P, Nyombayire J, Karita E, Ingabire R, Edward V, Muturi-Kioi V, Maenza J, Shapiro AE, McElrath MJ, Edupuganti S, Taylor BS, Diemert D, Ozorowski G, Koup RA, Montefiori D, Ward AB, Karlsson Hedestam GB, Tomaras G, Hunt DJ, Muema D, Sok D, Laufer DS, Andrews SF, Nduati EW, Schief WR.
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Science
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July 31, 2025
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Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
Parks KR, Moodie Z, Allen MA, Yen C, Furch BD, MacPhee KJ, Ozorowski G, Heptinstall J, Hahn WO, Zheng Z, Lu H, Grant S, Domin E, Duff MO, Seese A, Marini-Macouzet C, Ballweber-Fleming L, Lee WH, Cottrell CA, Liguori A, Georgeson E, Alavi N, Kubitz M, Phelps N, Seaton KE, Cohen KW, Anderson MA, Mondal K, Laufer DS, Kublin JG, Ward AB, Hyrien O, De Rosa SC, Himansu S, Leav B, Reuter C, Tomaras GD, Montefiori D, Walsh SR, Frank I, Sobieszczyk ME, Goepfert PA, Stephenson KE, Baden LR, Van Tieu H, Keefer MC, Clark J, Riddler SA, Schief WR, McElrath MJ.
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Sci Transl Med
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July 30, 2025
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Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.
Ramezani-Rad P, Cottrell CA, Marina-Zárate E, Liguori A, Landais E, Torres JL, Myers A, Lee JH, Baboo S, Flynn C, McKenney K, Salcedo E, Zhou X, Kalyuzhniy O, Georgeson E, Phelps N, Lu D, Eskandarzadeh S, Menis S, Kubitz M, Groschel B, Alavi N, Jackson AM, Lee WH, Tran AS, Ben-Akiva E, Kaczmarek Michaels K, Diedrich JK, Enemuo CA, Lewis V, Pradhan A, Kasturi SP, Schiffner T, Steichen JM, Carnathan DG, Himansu S, Yates JR 3rd, Paulson JC, Ozorowski G, Irvine DJ, Silvestri G, Sok D, Ward AB, Crotty S, Schief WR.
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Sci Transl Med
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July 30, 2025
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