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Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery.
Li X, Krishnamurthy I, Mishra N, James NE, Chowdhury RR, Callaghan S, Somanathan A, Avillion G, Amereh K, Sekar T, Oberoi P, Zhu Y, Torres JL, Lee WH, Allen JD, Liang B, Giese G, Vo AL, Andrabi S, Jain I, Mergiya A, Capozzola T, He WT, Anzanello F, Habib R, Bibollet-Ruche F, Nedellec R, Sackett SD, Ozorowski G, Burton DR, Hahn BH, Shaw GM, Ward AB, Crispin M, Barnes CO, Andrabi R.
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bioRxiv
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Oct. 26, 2025
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Structure-guided discovery of Otopetrin 1 inhibitors reveals druggable binding sites at the intrasubunit interface.
Burendei B, Kaplan JP, Orellana GM, Liman ER, Forli S, Ward AB.
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Nat Commun
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Oct. 23, 2025
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Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation.
Kędzior M, Phulera S, Fernández-Quintero ML, Loeffler JR, Joyce C, Woehl J, Abbasi A, Karimi M, Aslanabadi A, Hojabri M, Zareidoodeji R, Atkinson B, Burgos EFP, Heredia A, Saye-Francisco K, Tran Q, Kim Y, Acosta-Puente F, Shahin L, Zhou A, Altman PX, Felbinger NR, Pierce BG, Sok D, Seaman MS, Burton DR, DeVico AL, Ward AB, Ozorowski G, Sajadi MM, Jardine JG.
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bioRxiv
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Oct. 23, 2025
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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
Mishra N, Liang B, Roark RS, Ghosh A, Callaghan S, Lee WH, Li X, Vo AL, Avillion G, Chowdhury RR, Habib RH, Bibollet-Ruche F, Giese G, Oberoi P, Amereh K, Somanathan A, Zhu Y, Zhang Y, Kassab M, Tjio L, Andrabi S, Reyes RA, Allen JD, James NE, Randall KN Jr, van der Maas L, Ben-Akiva E, Kacmarek-Michaels K, Plante S, Martella CL, Skelly AN, Singh A, Hurtado J, Dueker K, Capozzola T, Nedellec R, Ozorowski G, Lewis MM, Falcone S, Carfi A, Himansu S, Shapiro L, Crispin M, Hahn BH, Briney B, Irvine DJ, Burton DR, Ward AB, Batista FD, Kwong PD, Shaw GM, Andrabi R.
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bioRxiv
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Oct. 23, 2025
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Chimeric hemagglutinin-based universal influenza mRNA vaccine induces protective immunity and bone marrow plasma cells in rhesus macaques.
Styles TM, Akhtar A, Gu C, Neumann G, Muramatsu H, McPartlan JS, Talukder P, Gratz D, Stokdyk K, Turner HL, Ferguson JA, Rodriguez AJ, Loganathan M, Francis B, Abbad A, Chikh G, Tam YK, Qin ZS, Han J, Carreño JM, Ward AB, Chahal JS, Mandl CW, Pardi N, Kawaoka Y, Krammer F, Ahmed R, Amara RR.
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Cell Rep Med
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Oct. 21, 2025
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Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models.
Xie Z, Wang X, Yan Y, Steichen JM, Ma KM, Cottrell CA, Melzi E, Bottermann M, Villavicencio PM, Rantalainen K, Schiffner T, Warner JE, Weldon SR, Prum T, Ellis-Pugh JR, Torres JL, Jackson AM, Flynn CT, Ozorowski G, Himansu S, Carfi A, Ward AB, Nair U, Schief WR, Batista FD.
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Sci Immunol
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Oct. 17, 2025
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A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers.
Chaturbhuj DN, Sliepen K, Cupo A, Steinberg B, Kazimierczyk S, Munawar T, Kramer K, Yasmeen A, Andrade TG, Lee W-H, van der Maas L, Gibson G, Feliciano O, Del Moral Sanchez I, Schermer E, Bronson R, Benner A, Prabhakaran M, Mason R, Klasse PJ, Ward AB, Ozorowski G, Sanders RW, Moore JP.
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J Virol
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Sept. 23, 2025
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HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs.
Guenaga J, Adori M, Bale S, Phulera S, Zygouras I, Schleich FA, Dopico XC, Agrawal S, Ota M, Wilson R, Cluff J, Dzvelaia T, Mandolesi M, Walsh A, Melo MB, Verkoczy L, Irvine DJ, Corcoran M, Wilson IA, Carnathan D, Silvestri G, Ward AB, Ozorowski G, Karlsson Hedestam GB, Wyatt RT.
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bioRxiv
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Sept. 22, 2025
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GMP Manufacturing and Characterization of the HIV Booster Immunogen HxB2.WT.Core-C4b for Germline Targeting Vaccine Strategies.
Pallerla S, Kallur Siddaramaiah L, Mundsperger P, Katinger D, Fauland K, Kreismayr G, Weik R, Arslan O, Shen M, Ozorowski G, Lee WH, Ward AB, Baboo S, Diedrich JK, Yates JR 3rd, Paulson JC, Blumen T, Craig D, Swoyer R, Yuan M, Stamatatos L.
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Vaccines (Basel)
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Sept. 18, 2025
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Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques.
Sangesland M, Li N, Tsybovsky Y, Rodgers MD, Han J, Rodriguez AJ, Ferguson JA, Henry AR, Smith SC, Roberts-Torres J, Gillespie RA, Liu C, Merriam JS, Stephens T, Williams C, Walker E, Corcoran M, Ravichandran M, Creanga A, Andrews SF, Pierson TC, Karlsson Hedestam GB, Schramm CA, Reed DS, Douek DC, Zhou T, Ward AB, Kanekiyo M.
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Sci Transl Med
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Sept. 10, 2025
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CD16a pairs form the basal molecular subunit for the NK-cell ADCC lytic synapse.
Ross P, Cid T, Fernández Quintero M, Loeffler J, Fatima H, Leaman DP, Matthias J, Spencer K, Zwick MB, Henderson SC, Ward AB, Mace EM, Murin CD.
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J Immunol
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Sept. 1, 2025
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Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child.
Turner L, Nunez de Villavicencio Diaz T, Raghavan SSR, Kana IH, Lyimo E, Reitzel C, Wang CW, Berube E, Jensen RW, Loeffler JR, Fernández-Quintero ML, Theander TG, Lusingu JPA, Le Bihan T, Han X, Minja DTR, Ward AB, Ma B, Lavstsen T.
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Proc Natl Acad Sci U S A
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Aug. 26, 2025
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HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates.
Ma KM, Sutton HJ, Pratap PP, Steichen JM, Carnathan D, Quinn J, Kalyuzhniy O, Liguori A, Agrawal S, Baboo S, Madden P, Cottrell CA, Willis JR, Lee JH, Landais E, Hu X, Ramezani-Rad P, Ozorowski G, Lewis VR, Diedrich JK, Zhou X, Altheide TK, Phelps N, Georgeson E, Alavi NB, Lu D, Eskandarzadeh S, Kubitz M, Adachi Y, Mullen TM, Silva M, Melo MB, Himansu S, Irvine DJ, Burton DR, Yates JR 3rd, Paulson JC, Sok D, Wilson IA, Silvestri G, Ward AB, Crotty S, Schief WR.
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Sci Immunol
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Aug. 22, 2025
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Accelerated cGMP production of near-native HIV-1 Env trimers following electroporation transfection and immunogenicity analysis.
Bale S, Gustchina E, Guenaga J, Ayala V, Lee WH, Ozorowski G, Whitney S, Wilson R, Baboo S, Diedrich JK, Doyle ED, Hudacik L, Ben-Akiva E, Rodrigues KA, Irvine DJ, Yates JR 3rd, Paulson JC, Ward AB, Fouts T, Wyatt RT.
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NPJ Vaccines
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Aug. 20, 2025
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Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques.
Pratap PP, Cottrell CA, Quinn J, Carnathan DG, Bader DLV, Tran AS, Enemuo CA, Ngo JT, Richey ST, Gao H, Shen X, Greene KM, Hurtado J, Michaels KK, Ben-Akiva E, Lemnios A, Melo MB, Allen JD, Ozorowski G, Crispin M, Briney B, Montefiori D, Silvestri G, Irvine DJ, Crotty S, Ward AB.
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NPJ Vaccines
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Aug. 20, 2025
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CryoEM Structures of Antibodies Elicited by Germline-Targeting HIV MPER Epitope-Scaffolds.
Huang J, Swanson OM, Rantalainen K, Fernández-Quintero ML, Loeffler JR, Tingle R, Georgeson E, Phelps N, Ozorowski G, Schiffner T, Schief WR, Ward AB.
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bioRxiv
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Aug. 19, 2025
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Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryo-EM.
Ferguson JA, Raghavan SSR, Alzua GP, Bhavsar D, Huang J, Rodriguez AJ, Torres JL, Bottermann M, Han J, Krammer F, Batista FD, Ward AB.
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Sci Adv
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Aug. 15, 2025
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A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins.
Puente-Massaguer E, Andrade TG, Scherm MJ, Vasilev K, Abozeid H, Rodriguez AJ, Yueh J, Bhavsar D, Campbell JD, Yu D, Webby RJ, Kawaoka Y, Neumann G, Han J, Ward AB, Krammer F.
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bioRxiv
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Aug. 14, 2025
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Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3.
Jo G, Yamayoshi S, Ma KM, Swanson O, Torres JL, Ferguson JA, Fernández-Quintero ML, Huang J, Copps J, Rodriguez AJ, Steichen JM, Kawaoka Y, Han J, Ward AB.
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Nat Commun
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Aug. 1, 2025
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