Pre-Prints
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Title & Authors Journal Publication Date
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Title & Authors Journal Publication Date

EMHP: An accurate automated hole masking algorithm for single-particle cryo-EM image processing


Berndsen Z, Bowman C, Jang H, Ward AB
Now Published: 10.1093/bioinformatics/btx500
bioRxiv July 28, 2017

The Electron Microscopy Hole Punch (EMHP) is a streamlined suite of tools for quick assessment, sorting and hole masking of electron micrographs. With recent advances in single-particle electron cryo-microscopy (cryo-EM) data processing allowing for the rapid determination of protein structures using a smaller computational footprint, we saw the need for a fast and simple tool for data pre-processing that could run independent of existing high-performance computing (HPC) infrastructures. EMHP provides a data preprocessing platform in a small package that requires minimal python dependencies to function.